Col. Dave Lapan did not immediately give other details about the situation.
The aircraft lost contact with air traffic control Tuesday evening, officials from Joint Base Elmendorf-Richardson at Anchorage, Alaska, said Wednesday.
Gary Strasburg, an Air Force spokesman, told CNN that a pilot was in the single-seat aircraft during a routine training mission.
Contact was lost with the F-22 at 7:40 p.m. Alaska time (11:40 p.m. ET) on Tuesday.